Bearcats quarterback Jordan Hill will not return to the field, according to the school.
Hill, who tore his ACL in the preseason and has missed most of the last three games, will undergo surgery on his right knee.
He is expected to miss six weeks, according the school’s website.
The Bearcat is still without its second-leading scorer, who suffered a left ankle injury in the fourth quarter.
“I want to thank our coaching staff and players for their understanding during this difficult time,” coach Chris Sabin said in a statement.
“This is a very difficult time for the Bearcatin family and the entire program.
We wish Jordan and his family all the best as they begin to heal and move forward.
Beside him, the Beacats’ secondary is still reeling from the loss of former All-American and Heisman Trophy winner Jourdan Lewis, who also tore his right ACL and MCL.
Hill played in just two games last season.
He has yet to play in a regular season game this season, having missed two games due to injury.
Cincinnati is in a position similar to Bearcatts where it needs Hill to play well to win a playoff game, a position Hill has shown himself to be at times this year.
Bearcats coach Andy Holton, a former offensive coordinator at Alabama, was promoted to head coach on Dec. 2 after the firing of former coach Chad Morris.
This is the third season in a row that Hill has missed a game due to a concussion.
He was one of the main reasons for the Bengals winning the AFC North in 2016.
Holton was promoted from his previous position of offensive coordinator to offensive coordinator/defensive coordinator on Oct. 23, 2016.